The wrath of God is poured out. Rev 16:2 So the first angel went and poured out his bowl on the earth, and harmful and painful sores came upon the people who bore the mark of the beast and worshipped its image.

This gives us a bit of a timeline. The Antichrist makes everyone get the Mark, and although, much of it is in place, I still think it will take a year for this to be completed. Then the wrath starts to pour out, for you need to have the mark to get the sores. We have observed that luciferase causes the skin to become sensitive to light. We already know how these sores come about. They should have the complete mark, and that means the mark on the hand or the forehead. When we see these sores appear, we will know major calamities are about to strike. In Revelation 8, we see this event as Then the angel took the censer and filled it with fire from the altar and threw it on the earth, the vegetation being burnt.